Biophysical principles and computational modeling of deep brain stimulation
Ng PR, Bush A, Vissani M, McIntyre CC, Richardson RM
Neuromodulation · 2024 · doi:10.1016/j.neurom.2023.04.471
A review of the biophysical principles and computational modeling that underpin deep brain stimulation. We cover how applied electric fields interact with neural tissue, volume-of-tissue-activated estimates, multi-compartment axon cable models, and network-level simulations, and how these models increasingly inform electrode targeting, contact selection, programming, and the rational design of next-generation neuromodulation therapies.