Impulsivity is associated with firing regularity in parkinsonian ventral subthalamic nucleus
Vissani M, Micheli F, Pecchioli G, Ramat S, Mazzoni A
Ann. Clinical & Translational Neurology · 2022 · doi:10.1002/acn3.51530
Impulsive-compulsive behaviors (ICB) are over-represented in Parkinson's disease (PD) patients. Neurons in the ventral subthalamic nucleus (STN) might play a predominant role in the modulation of impulsivity. We characterized the firing regularity of 742 subthalamic neurons from 24 PD patients (12 ICB+ and 12 ICB-) in an OFF medication state. We computed the firing regularity in the dorsal and ventral STN regions, and we compared their performance in discriminating ICB patients. Regularity of ventral neurons in ICB+ patients is higher and supports a significant discrimination between the two cohorts. These results substantiate a ventral location of neurons involved in impulsivity.